|Based in the School of Chemistry at Newcastle University, we are organic chemists performing creative and imaginative research in the fields of polymer and supramolecular chemistry. Our interests lie in applying organic and polymer syntheses with supramolecular principles to development responsive and adaptable nanoparticles and materials with potential applications in molecular recognition and sensing, medicine and materials science. Here you can find out more about what’s going on in our laboratory, including our current and research. The DAF group are based in the School of Chemistry's Chemical Nanoscience Laboratory, and have received generous funding from EPSRC, EU-FP7, The Royal Society, and the regional development agency OneNorthEast.|
News and Research Highlights
Templating carbohydrate polymers with lectins
Carbohydrate-protein interactions are important in biology, playing important roles in cell-cell interactions and infections caused by viral and bacterial pathogens. For example, cholera is caused by proteins secreted by the Vibrio cholera bacteria and which start their process of cell infection by binding to carbohydrates displayed on the surfaces of cells. Consequently, there has been much effort to understand better carbohydrate-protein interactions with the aim of developing effective inhibitors which may lessen the effects of the cholera toxin.
In work described in Organic and Biomolecular Chemistry (click here), we describe a conceptually new method for preparing synthetic polymers which can bind to heat labile toxin, a carbohydrate binding protein which is structurally very similar to cholera toxin. Our method uses the protein itself to act as a template, onto which the polymer binds and selects carbohydrate residues which improve its binding affinity from a pool of residues. These residues can adapt their positions upon the polymer to maximize their binding with toxin. We show that the polymer is able to enhance its binding by about one order of magnitude, selecting those carbohydrate residues which presumably promote stronger binding and discarding those which do not. We anticipate that we will be able to build upon this proof of concept and develop polymers which can bind more strongly to carbohydrate-binding proteins.
Mimicking nature with synthetic macromolecules capable of recognition
Biological systems have evolved sophisticated machinery to assemble polymeric receptors capable of molecular recognition. For example, antibodies are a key part of the body's immune system, playing key roles in recognizing unwanted pathogens, and these antibodies are simply polymers of amino acids which possess the required sequence and are folded in the correct way to obtain highly selective binding towards antigens. Although such precise levels of control are currently inaccessible to chemists, impressive progress towards the realization of synthetic analogues of antibodies and other proteins has been made. In our recent Nature Chemistry perspective, we highlight and critically evaluate some of the most impressive work in the field. Click here to read.
January 2015 Clare's paper describing a new approach towards the design of carbohydrate polymers which bind lectins is published in Organic and Biomolecular Chemistry. Click here.
December 2014 Ben Murray (2009-2011) will soon be joining the faculty of Hull University as a lecturer in Inorganic Chemistry. Well done to Ben!
November 2014 DAF presented the work of Dan Coleman and Marta Pujol on siRNA delivery at the Emerging Nanomaterials for Healthcare symposium at Warwick University.
October 2014 The group are happy to welcome Dr Antonio Ruiz-Sanchez and Ahmed Ejaz. Antonio will be working on anti-biofouling coatings and Ahmed will be working on single-chain polymer nanoparticles.
September 2014 Niza’s paper on composite nanoparticles which can simultaneously display enhanced luminescence and Raman spectra has just been published in Chemical Communications. Click here to read article.
August 2014 Congratulations to Clare for successfully defending her PhD dissertation. Proving that quality always beats quantity, her thesis came in at less than 100 pages. Clare is now the third PhD student to graduate from the DAF group. Clare will be joining the lab of Dr Bruce Turnbull at Leeds University on an EPSRC Doctoral Fellowship.
June 2014 Welcome to Drs Claudia Ventura and Luke Dixon, who have joined the group to work on novel anti-biofouling coatings for marine applications.
March 2014 DAF presented recent work from the group at the ACS meeting in Dallas. Together with Prof Brent Sumerlin of University of Florida, he also co-organized a very successful symposium focused on Dynamic Covalent Chemistry in Polymer Science which featured talks from just about all other groups currently active in the field, including Profs Stuart Rowan, Hideyuki Otsuka, Fraser Stoddart and krzysztof Matyjaszewski.
Seventy life-size bronze steers make their way through Pioneer Plaza in downtown Dallas.
February 2014 Clare presented her recent work on Polymer-Scaffolded Dynamic Combinatorial Libraries at the International Conference on Nanoscience and Nanotechnology 2014 in Adelaide Australia.